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Endorphin precursors are primarily produced in the pituitary gland. Endorphins are released from the pituitary gland, typically in response to pain, and can act in both the central nervous system CNS and the peripheral nervous system PNS.
In turn, inhibition of GABA increases the production and release of dopamine , a neurotransmitter associated with pleasure. Endorphins play a major role in the body's inhibitory response to pain.
For example, endorphin release is responsible for producing the euphoric state in cases such as runner's high, sex , orgasm , listening to music, and eating appetizing food such as chocolate.
Endorphin production can also be triggered by vigorous aerobic exercise. Regular intense exercise may cause the brain to downregulate the production of endorphins in periods of rest to maintain homeostasis , causing a person to exercise more intensely in order to receive the same feeling.
From Wikipedia, the free encyclopedia. For other uses, see Endorphins disambiguation. This section needs expansion.
You can help by adding to it. December Folia Biologica. Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla.
International Union of Basic and Clinical Pharmacology. Retrieved 28 December Morphine occurs endogenously Future Medicinal Chemistry.
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The sentence contains offensive content. Cancel Submit. Your feedback will be reviewed. Want to learn more? Endorphins make problems look smaller and make you feel better about your life.